Iron-handling Disorder
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We do not provide kits. Please collect the sample following the sample collection and shipping instructions before ordering a test.
Signs become apparent at a young age and include lethargy, weight loss, growth retardation, exercise intolerance, and weakness.
Autosomal recessive
Unpublished
2-2 (Homozygous Disease Variant)
Unhealthy (Affected)
Homozygous Affecteds (2-2) are expected to develop signs consistent with Iron-Refractory Iron Deficiency Anemia (IRIDA) and all of their offspring will inherit a disease variant allele. Parents, offspring and relatives should also be tested. You may choose to contact us for a consultation on the management of this disease. 1 = Normal allele; 2 = Variant allele.
1-2 (Heterozygous)
Healthy (Carrier)
Heterozygous Carriers (1-2) are not expected to develop signs of Iron-Refractory Iron Deficiency Anemia (IRIDA) but each of their offspring has a chance of inheriting a disease variant allele. Parents, offspring and relatives should also be tested. 1 = Normal allele; 2 = Variant allele.
1-1 (Homozygous Normal)
Healthy (Normal, Clear)
Homozygous Normals (1-1) are not expected to develop signs of Iron-Refractory Iron Deficiency Anemia (IRIDA) and none of their offspring will inherit the disease variant allele. 1 = Normal allele; 2 = Variant allele.
Naigamwalla DZ, Webb JA, Giger U. Iron deficiency anemia. Can Vet J. 2012 Mar;53(3):250-6. PMID: 22942439; PMCID: PMC3280776.